Natural Approaches to Targeting Inflammation in Psoriasis: Beyond Traditional Medicine

Disclaimer: This is for informational and inspirational purposes only, based on common holistic perspectives and research. It does not replace professional medical care—work with your doctor for personalized treatment, especially when considering alternatives to biologics or pills.

Psoriasis involves overactive immune pathways, like the IL-17/IL-23 axis, where these cytokines drive inflammation and plaque formation. Western medicine often uses injections (biologics like secukinumab for IL-17 or guselkumab for IL-23) or pills (e.g., deucravacitinib) to directly inhibit these signals, leading to rapid skin clearing in many. However, some seek natural ways to modulate these pathways holistically, focusing on diet, herbs, and lifestyle for gentler, supportive effects.

Natural compounds show promise in preclinical studies and small trials for inhibiting IL-17/IL-23 indirectly by suppressing Th17 cells, NF-κB, or related inflammation:

• Curcumin (from turmeric): Reduces IL-17/IL-23 production and Th17 activity; bioavailable forms may enhance effects, with some pilot trials showing downregulation of these cytokines in treated lesions.

• Resveratrol (in grapes/berries): Inhibits Th17 differentiation and IL-17 signaling.

• Other mentions: Ursolic acid, boswellic acids (frankincense), and sulforaphane (broccoli) suppress inflammatory pathways.

These mimic biologic mechanisms but are milder—combine with anti-inflammatory diets for synergy. For example, the Mediterranean diet's omega-3s and antioxidants may naturally lower these cytokines over time.

Holistic stories often highlight gradual improvements through these, without relying solely on meds—more on that in companion pieces.

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